Your browser doesn't support javascript.
loading
Differential longitudinal decline on the Mini-Mental State Examination in frontotemporal lobar degeneration and Alzheimer disease.
Tan, Kay See; Libon, David J; Rascovsky, Katya; Grossman, Murray; Xie, Sharon X.
Afiliação
  • Tan KS; Departments of *Biostatistics and Epidemiology ‡Neurology, Perelman School of Medicine, University of Pennsylvania †Department of Neurology, Drexel University College of Medicine, Philadelphia, PA.
Alzheimer Dis Assoc Disord ; 27(4): 310-5, 2013.
Article em En | MEDLINE | ID: mdl-23314064
OBJECTIVE: To examine how phenotype affects longitudinal decline on the Mini-Mental State Examination (MMSE) in patients with frontotemporal lobar degeneration (FTLD) and Alzheimer disease (AD). BACKGROUND: The MMSE is the most commonly administered assessment for dementia severity; however, the effects of phenotype on longitudinal MMSE performance in FTLD and AD have not been extensively studied. METHODS: Data from 185 patients diagnosed with AD (n=106) and 3 FTLD (n=79) phenotypes [behavioral variant frontotemporal dementia (bvFTD), nonfluent agrammatic variant of primary progressive aphasia (nfaPPA), and semantic variant PPA (svPPA)] were collected for up to 52 months since initial evaluation. RESULTS: Differential rates of decline were noted in that MMSE scores declined more precipitously for AD and svPPA compared with bvFTD and nfaPPA patients (P=0.001). The absolute 4-year MMSE decline given median baseline MMSE for bvFTD [14.67; 95% confidence interval (CI), 14.63-14.71] and nfaPPA (11.02; 95% CI, 10.98-11.06) were lower than svPPA (22.32; 95% CI, 22.29-22.34) or AD (22.24; 95% CI, 22.22-22.26). CONCLUSIONS: These data suggest that within-group AD and FTLD phenotypes present distinct patterns of longitudinal decline on the MMSE. MMSE may not be adequately sensitive to track disease progression in some phenotypes of FTLD.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escalas de Graduação Psiquiátrica Breve / Progressão da Doença / Degeneração Lobar Frontotemporal / Doença de Alzheimer Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimer Dis Assoc Disord Assunto da revista: NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2013 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escalas de Graduação Psiquiátrica Breve / Progressão da Doença / Degeneração Lobar Frontotemporal / Doença de Alzheimer Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimer Dis Assoc Disord Assunto da revista: NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2013 Tipo de documento: Article País de publicação: Estados Unidos