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[Diastolic dysfunction in patients with human inmunodeficiency virus. Tissue Doppler study]. / Disfuncion diastolica en pacientes infectados con el virus de inmunodeficiencia humana. Estudio con Doppler tisular.
Article em Es | MEDLINE | ID: mdl-23286536
UNLABELLED: The heart has rarely been studied in patients infected with HIV. Diastolic dysfunction is the most frequently observed alteration , which could be due to direct viral action on the myocardium or due to autoimmune mechanism or concomitant infections by cardiotropic virus. The Doppler tissue is a more effective tool than the trans-mitral one to evaluate the diastolic function since is not influenced by preload, afterload or heart rate. OBJECTIVES: To study the prevalence of the left ventricular diastolic dysfunction (DDVI) in the HIV (+) group of patients, without symptoms or diagnosis of heart-disease and to analyze their relationship with the CD4 levels and the viral charge. MATERIAL AND METHODS: We prospectively studied 50 HIV(+) patients with no symptoms of cardiac involvement who underwent an echocardiogram using Doppler tissue compared with 50 healthy persons matched sex and age as control group. RESULTS: The infection of HIV was associated with DDVI and with CD4 Lymphocytes levels (p<0,05). The association between DDVI and viral load was not found. CONCLUSIONS: There is an association between the HIV infection and the presence of DDVI in asymptomatic patients. The long term monitoring studies should be considered in HIV (+) patients with silent diastolic dysfunction to evaluate their possible progression to the systolic dysfunction.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Disfunção Ventricular Esquerda Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: Es Revista: Rev Fac Cien Med Univ Nac Cordoba Ano de publicação: 2012 Tipo de documento: Article País de publicação: Argentina
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Disfunção Ventricular Esquerda Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: Es Revista: Rev Fac Cien Med Univ Nac Cordoba Ano de publicação: 2012 Tipo de documento: Article País de publicação: Argentina