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Higher maternal body mass index is associated with an increased risk for later type 2 diabetes in offspring.
Juonala, Markus; Jääskeläinen, Paula; Sabin, Matthew A; Viikari, Jorma S A; Kähönen, Mika; Lehtimäki, Terho; Seppälä, Ilkka; Hutri-Kähönen, Nina; Taittonen, Leena; Jokinen, Eero; Laitinen, Tomi; Magnussen, Costan G; Raitakari, Olli T.
Afiliação
  • Juonala M; Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland. markus.juonala@utu.fi
J Pediatr ; 162(5): 918-23.e1, 2013 May.
Article em En | MEDLINE | ID: mdl-23260097
OBJECTIVES: To investigate whether the body mass index (BMI) of a child's mother is associated with an increased future risk of type 2 diabetes, independent of genetic risk or childhood metabolic, behavioral, and environmental factors. STUDY DESIGN: The analyses were based on the Cardiovascular Risk in Young Finns Study including 1835 individuals aged 3-18 years at baseline with data on maternal BMI, childhood metabolic factors, as well as 34 newly identified type 2 diabetes susceptibility alleles. These subjects were then followed-up over 21-27 years. RESULTS: Maternal BMI (OR for 1-SD increase 1.54 [95% CI 1.12-2.11], P = .008) and child's systolic blood pressure (1.54 [1.01-2.35], P = .04) were significantly associated with increased odds for later type 2 diabetes, in a multivariable analysis adjusted for age, sex, type 2 diabetes genetic risk score, childhood BMI, insulin, lipids, dietary factors, socioeconomic status, and mother's age, and history of type 2 diabetes. A risk prediction model, which included maternal BMI status outperformed one which utilized only child's BMI data (area under the receiver operating characteristic curve 0.720 vs 0.623, P = .02). The inclusion of genetic risk score and other baseline risk variables did not additionally improve prediction (area under the receiver operating characteristic curve 0.720 vs 0.745, P = .40). CONCLUSIONS: Maternal BMI is a useful variable in determining offspring risk of developing type 2 diabetes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Índice de Massa Corporal / Diabetes Mellitus Tipo 2 Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Pediatr Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Finlândia País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Índice de Massa Corporal / Diabetes Mellitus Tipo 2 Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Pediatr Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Finlândia País de publicação: Estados Unidos