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Role of TLR-2 and fungal surface antigens on innate immune response against Sporothrix schenckii.
Negrini, Thais de C; Ferreira, Lucas S; Alegranci, Pâmela; Arthur, Rodrigo A; Sundfeld, Pedro P; Maia, Danielle C G; Spolidorio, Luis C; Carlos, Iracilda Z.
Afiliação
  • Negrini Tde C; Department of Clinical Analysis, Araraquara School of Pharmaceutical Sciences, São Paulo State University, SP, Brazil.
Immunol Invest ; 42(1): 36-48, 2013.
Article em En | MEDLINE | ID: mdl-23231043
Sporotrichosis is an infection caused by the dimorphic fungus Sporothrix schenckii. Toll-like receptors (TLRs) play an important role in immunity, since they bind to pathogen surface antigens and initiate the immune response. However, little is known about the role of TLR-2 and fungal surface antigens in the recognition of S. schenckii and in the subsequent immune response. This study aimed to evaluate the involvement of TLR-2 and fungal surface soluble (SolAg) and lipidic (LipAg) antigens in phagocytosis of S. schenckii and production of immune mediators by macrophages obtained from WT and TLR-2(-/-) animals. The results showed that TLR-2(-/-) animals had had statistical lower percentage of macrophages with internalized yeasts compared to WT. SolAg and LipAg impaired phagocytosis and immunological mediator production for both WT and TLR-2(-/-). The absence of TLR-2 led to lower production of the cytokines TNF-α, IL-1ß, IL-12 and IL-10 compared to WT animals. These results suggest a new insight in relation to how the immune system, through TLR-2, recognizes and induces the production of mediators in response to the fungus S. schenckii.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esporotricose / Sporothrix / Receptor 2 Toll-Like / Macrófagos / Antígenos de Fungos Limite: Animals Idioma: En Revista: Immunol Invest Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esporotricose / Sporothrix / Receptor 2 Toll-Like / Macrófagos / Antígenos de Fungos Limite: Animals Idioma: En Revista: Immunol Invest Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido