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Therapeutic efficacy and safety of methotrexate + leflunomide in Colombian patients with active rheumatoid arthritis refractory to conventional treatment.
Londono, John; Santos, Ana Maria; Santos, Pedro Ivan; Cubidez, Maria Fernanda; Guzman, Claudia; Valle-Oñate, Rafael.
Afiliação
  • Londono J; Universidad de La Sabana, Campus Universitario del Puente del Comun, Km. 7 Autopista Norte de Bogota D.C., Chia, Colombia. john.londono@unisabana.edu.co
Rev Bras Reumatol ; 52(6): 837-45, 2012 Dec.
Article em En, Pt | MEDLINE | ID: mdl-23223695
INTRODUCTION: The combination of methotrexate (MTX) + leflunomide (LFN) has been shown to be effective in the treatment of RA. Its safety has been questioned. OBJECTIVE: To evaluate the effectiveness and safety of the combination of MTX + LFN in patients with active RA. METHODS: This was a 24-week multicenter study, which included 88 patients with active disease despite consistent treatment with methotrexate and prednisolone. RESULTS: We included 78 women (88%) and 10 men. The age was 51.3 ± 12.4 years, and the evolution of disease was 8 ± 6.8 years. Patients had active disease, which was indicated by a median of IQR of 10.0 (7.0-13.0) for swollen and of 14.0 (18.0-10.0) for tender joints for the whole group. The ACR responses achieved at week 24 were: ACR20: 76.0%; ACR50: 67.1%; ACR70: 23.9%. There was improvement in the activity of disease: DAS-28 score: 5.8 ± 1.2 at baseline vs. 3.8 ± 1.6 at week 24 (P = 0.000). The most significant adverse event was elevation of transaminases in eight patients (26%). Eight patients were withdrawn due to adverse events: four due to the elevation of transaminases, and one each due to diabetes insipidus, rash, diabetes mellitus and osteomuscular pain. CONCLUSION: The combination of MTX + LFN is effective for treating RA in patients for whom conventional treatment has failed. Strict medical and laboratory control is to be enforced for safety.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Metotrexato / Isoxazóis Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En / Pt Revista: Rev Bras Reumatol Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Metotrexato / Isoxazóis Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En / Pt Revista: Rev Bras Reumatol Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Brasil