Are increased Foxp3+ regulatory T cells responsible for immunosuppression during HTLV-1 infection? Case reports and review of the literature.
BMJ Case Rep
; 20122012 Nov 27.
Article
em En
| MEDLINE
| ID: mdl-23188837
Research of human T lymphotropic virus type I (HTLV-1)-associated diseases is mostly focused on inflammatory and lymphoproliferative disorders. However, the immunosuppressive consequences of HTLV-1 infection are frequently ignored. In developing countries where exposure to parasitic and other tropical diseases is frequent, the burden of disease is significantly increased by opportunistic infections. Regulatory T cells (Tregs) are a CD4 T-cell subset capable of suppressing effector responses. During HTLV-1 infection, CD4+Foxp3+ cells are increased in HTLV-1-associated leukaemia/lymphoma (ATLL) as well as in non-leukaemic presentations. However, controversy exists regarding the actual regulatory function of these cells. In this report, we present two cases of HTLV-1 ATLL complicated by parasitic organisms and we provide a brief review of the literature regarding FoxP3+ regulatory T cells and their role as a possible mechanism for the immunosuppressive manifestations that take place during HTLV-1 infection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Escabiose
/
Estrongiloidíase
/
Tinha
/
Infecções Oportunistas
/
Infecções por HTLV-I
/
Leucemia-Linfoma de Células T do Adulto
/
Linfócitos T CD4-Positivos
/
Strongyloides stercoralis
/
Linfócitos T Reguladores
/
Entamoeba histolytica
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
/
Animals
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
BMJ Case Rep
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Peru
País de publicação:
Reino Unido