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Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report.
Bohn, Olga L; de León, Eric Acosta-Ponce; Lezama, Oscar; Rios-Luna, Nina P; Sánchez-Sosa, Sergio; Llombart-Bosch, Antonio.
Afiliação
  • Bohn OL; Department of Pathology, Christus Mugerza UPAEP University Hospital, Puebla, 72000, Mexico. olga.bohn@gmail.com
Diagn Pathol ; 7: 154, 2012 Nov 07.
Article em En | MEDLINE | ID: mdl-23134683
Primary sarcomas of the major blood vessels can be classified based on location in relationship to the wall or by histologic type. Angiosarcomas are malignant neoplasms that arise from the endothelial lining of the blood vessels; those arising in the intimal compartment of pulmonary artery are rare. We report a case of pulmonary artery angiosarcoma in a 36-year old female with pulmonary masses. The patient had no other primary malignant neoplasm, thus excluding a metastatic lesion. Gross examination revealed a thickened right pulmonary artery and a necrotic and hemorrhagic tumor, filling and occluding the vascular lumen. The mass extended distally, within the pulmonary vasculature of the right lung. Microscopically, an intravascular undifferentiated tumor was identified. The tumor cells showed expression for vascular markers VEGFR, VEGFR3, PDGFRa, FGF, Ulex europaeus, FVIII, FLI-1, CD31 and CD34; p53 was overexpressed and Ki67 proliferative rate was increased. Intravascular angiosarcomas are aggressive neoplasms, often associated with poor outcome.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artéria Pulmonar / Neoplasias Vasculares / Erros de Diagnóstico / Histiocitoma Fibroso Maligno / Hemangiossarcoma Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Female / Humans Idioma: En Revista: Diagn Pathol Assunto da revista: PATOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artéria Pulmonar / Neoplasias Vasculares / Erros de Diagnóstico / Histiocitoma Fibroso Maligno / Hemangiossarcoma Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Female / Humans Idioma: En Revista: Diagn Pathol Assunto da revista: PATOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido