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Difficult clinical management of anti-tuberculosis DRESS syndrome.
Palmero, D; Castagnino, J; Musella, R M; Mosca, C; González Montaner, P; de Casado, G C.
Afiliação
  • Palmero D; División Tisioneumonología, Hospital de Infecciosas Dr F J Muñiz, Buenos Aires, Argentina. djpalmero@intramed.net
Int J Tuberc Lung Dis ; 17(1): 76-8, 2013 Jan.
Article em En | MEDLINE | ID: mdl-23114284
We describe 11 cases of anti-tuberculosis DRESS (drug-related rash with eosinophilia and systemic symptoms) syndrome, a potentially serious complication of treatment that led to interruption of treatment for prolonged periods, systemic corticosteroid use and the resumption of treatment with less effective regimens. All patients had rash and toxic hepatitis, one died of multi-organ failure and, contrary to expectations, the evolution of tuberculosis (advanced in most cases) did not progress under corticosteroid treatment. The drug most frequently involved was rifampicin, while retreatment schemes included, in most cases, levofloxacin, ethambutol, streptomycin and cycloserine.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxidermias / Eosinofilia / Exantema / Doença Hepática Induzida por Substâncias e Drogas / Antituberculosos Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Int J Tuberc Lung Dis Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Argentina País de publicação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxidermias / Eosinofilia / Exantema / Doença Hepática Induzida por Substâncias e Drogas / Antituberculosos Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Int J Tuberc Lung Dis Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Argentina País de publicação: França