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Association between HLA-DRB1* polymorphisms and hepatitis B infection in a brazilian population.
Corrêa, Bruno de Melo; Lopes, Edmundo Pessoa de Almeida; Albuquerque, Maria de Fátima Pessoa Militão de; Dourado, Lúcia.
Afiliação
  • Corrêa Bde M; Fundação de Hematologia e Hemoterapia de Pernambuco, Universidade Federal de Pernambuco, Recife, PE, Brazil. brunomelocorrea@yahoo.com.br
Rev Assoc Med Bras (1992) ; 58(5): 537-42, 2012.
Article em En | MEDLINE | ID: mdl-23090223
OBJECTIVE: The aim of the present study was to determine the genotype association for alleles of class II human leukocyte antigens (HLA) in the DRB1* locus among blood donors at the Fundação Hemope (Brazil) infected by or immunized for the hepatitis B virus (HBV). METHODS: A case-control study was performed, comprising a group of individuals infected by HBV and a control group of immunized individuals at a proportion of 1:4. Blood samples were taken for the HLA typing of the DRB1* locus. Univariate and multivariate analyses were performed for the assessment of associations between the categorical variables using the chi-squared test and Fisher's exact test. RESULTS: A total of 320 blood donors were analyzed (241 males [75%] and 79 females [25%] with a mean age of 39 years). The case group consisted of 64 HBV-infected donors and the control group was composed of 256 HBV-immunized donors. The multivariate analysis stratified by gender revealed that the DRB1*09 allele was associated with infected male donors (p = 0.016) and the DRB1*08 allele was associated with infected donors aged 39 years or younger (p = 0.031). CONCLUSION: The results of the present study reveal that younger blood donors and male blood donors who respectively exhibit the DRB1*08 and DRB1*09 alleles are more susceptible to intensification of HBV infection.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Cadeias HLA-DRB1 / Hepatite B / Anticorpos Anti-Hepatite B / Antígenos da Hepatite B Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Cadeias HLA-DRB1 / Hepatite B / Anticorpos Anti-Hepatite B / Antígenos da Hepatite B Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil