Fetal brain disruption sequence.
J Pediatr
; 116(3): 383-6, 1990 Mar.
Article
em En
| MEDLINE
| ID: mdl-2308027
The fetal brain disruption sequence is a recognizable pattern of defects that includes moderate to profound microcephaly, overlapping sutures, occipital bone prominence, and scalp rugae. The condition is postulated to arise from partial brain disruption during the second or third trimester with subsequent fetal skull collapse resulting from decreased intracranial hydrostatic pressure. Proposed causes include prenatal viral or parasitic infections and vascular disruptions. We report seven infants with the fetal brain disruption sequence. Two of these patients died. A changing phenotype with time was seen in three. Recognition of this phenotype is critical because the condition has a uniformly poor prognosis for infants but the recurrence risk in future pregnancies is low.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Crânio
/
Anormalidades Múltiplas
/
Encéfalo
/
Microcefalia
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
J Pediatr
Ano de publicação:
1990
Tipo de documento:
Article
País de publicação:
Estados Unidos