Your browser doesn't support javascript.
loading
The MHC2TA gene polymorphisms are not associated with restenosis after coronary stenting in Mexican patients.
Delgadillo, Hilda; Vargas-Alarcón, Gilberto; Gómez-Monterrosas, Omar; Martínez-Rodríguez, Nancy; Ramírez-Fuentes, Silvestre; Carrillo-Sánchez, Silvia; Peña-Duque, Marco Antonio; Martínez-Ríos, Marco Antonio; Pérez-Méndez, Oscar; Fragoso, José Manuel.
Afiliação
  • Delgadillo H; Interventional Genetic Study Group in Cardiovascular Disease's, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
Arch Cardiol Mex ; 82(3): 208-13, 2012.
Article em En | MEDLINE | ID: mdl-23021357
OBJECTIVE: The aim of this study was to test for association between MHC2TA gene polymorphisms and risk for restenosis after coronary stent placement in a group of Mexican patients. METHODS: The MHC2TA-168A>G (rs3087456), 1614C>G (rs4774), and 2536G>A (rs2229320) single nucleotide polymorphisms were genotyped using 5' exonuclease TaqMan genotyping assays in a group of 202 patients, who underwent coronary artery stenting. Basal and procedure coronary angiography were analyzed, looking for angiographic predictors of restenosis and follow-up angiography was performed to screen for binary restenosis. RESULTS: The results obtained in this study showed that the frequency of the three polymorphisms studied was similar in patients with and without restenosis. Univariate analysis showed that the use of drug-eluting stent (DES) reduces the risk of developing restenosis (p<0.001, OR=0.26). In contrast, the diameter<2.5mm of the stent and bifurcations increased the risk of developing restenosis (p=0.049, OR=1.74 and p=0.041, OR=1.8). CONCLUSION: The present study suggests that the MHC2TA polymorphisms are not involved in the risk of developing restenosis after coronary stent placement.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Stents / Transativadores / Polimorfismo de Nucleotídeo Único / Reestenose Coronária Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Arch Cardiol Mex Assunto da revista: CARDIOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: México País de publicação: México
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Stents / Transativadores / Polimorfismo de Nucleotídeo Único / Reestenose Coronária Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Arch Cardiol Mex Assunto da revista: CARDIOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: México País de publicação: México