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Insulin resistance can impair reduction on carotid intima-media thickness in obese adolescents.
Arq Bras Cardiol ; 99(4): 892-8, 2012 Oct.
Article em En, Pt | MEDLINE | ID: mdl-22936026
BACKGROUND: The atherosclerotic process at the endothelial level begins in early ages and seems to be associated with obesity and its comorbidities as insulin resistance. OBJECTIVE: The aim of this study was to verify the influence of insulin resistance on inflammatory and subclinical markers of atherosclerosis in obese adolescents. METHODS: Sixty-six post-pubescent obese adolescents were divided in two groups according to homeostasis model assessment of insulin resistance (HOMA-IR) measurement: with insulin resistance (IR) n=39 and without insulin resistance (NIR) n=27, and submitted to an interdisciplinary intervention over the course of 1 year. Common carotid artery intima-media thickness (cIMT), visceral and subcutaneous adipose tissue was determined by ultrasound. Body composition, blood pressure, HOMA-IR, lipid profile and adipokines concentrations [leptin, adiponectin, and plasminogen activator inhibitor type (PAI-1)] were analyzed before and after the therapy. RESULTS: Both groups presented significant improvements in body composition, inflammatory state (reduction of leptin and PAI-1 concentration; increasing of plasma adiponectin) and reduction of cIMT. Only NIR group showed positive correlation between changes in visceral fat (∆Visceral) and changes in cIMT (∆ cIMT) (r = 0.42; p < 0.05). Simple linear regression analyze revealed ∆Visceral to be an independent predictor to reduction of cIMT in this group (R2 adjusted = 0.14, p = 0.04). The final values of cIMT remained significantly higher in IR group when compared to NIR group. CONCLUSION: The presence of insulin resistance can impair changes in cIMT leading to early development of atherosclerosis in obese adolescents submitted to an interdisciplinary intervention..
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Doenças das Artérias Carótidas / Espessura Intima-Media Carotídea / Obesidade Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En / Pt Revista: Arq Bras Cardiol Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Doenças das Artérias Carótidas / Espessura Intima-Media Carotídea / Obesidade Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En / Pt Revista: Arq Bras Cardiol Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil