Ancestral effect on HOMA-IR levels quantitated in an American population of Mexican origin.
Diabetes Care
; 35(12): 2591-3, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22891255
OBJECTIVE: An elevated insulin resistance index (homeostasis model assessment of insulin resistance [HOMA-IR]) is more commonly seen in the Mexican American population than in European populations. We report quantitative ancestral effects within a Mexican American population, and we correlate ancestral components with HOMA-IR. RESEARCH DESIGN AND METHODS: We performed ancestral analysis in 1,551 participants of the Cameron County Hispanic Cohort by genotyping 103 ancestry-informative markers (AIMs). These AIMs allow determination of the percentage (0-100%) ancestry from three major continental populations, i.e., European, African, and Amerindian. RESULTS: We observed that predominantly Amerindian ancestral components were associated with increased HOMA-IR (ß = 0.124, P = 1.64 × 10(-7)). The correlation was more significant in males (Amerindian ß = 0.165, P = 5.08 × 10(-7)) than in females (Amerindian ß = 0.079, P = 0.019). CONCLUSIONS: This unique study design demonstrates how genomic markers for quantitative ancestral information can be used in admixed populations to predict phenotypic traits such as insulin resistance.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Diabetes Care
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Estados Unidos