Experimental visceral leishmaniasis: sequential events of granuloma formation at subcutaneous inoculation site.
Int J Exp Pathol
; 71(6): 791-7, 1990 Dec.
Article
em En
| MEDLINE
| ID: mdl-2278823
Hamsters were inoculated with IO7 Leishmania (Leishmania) chagasi amastigotes in the hind footpads and killed at 7, 15, 30, 45, 60, 75 and 90 days after infection. We observed mononuclear inflammatory infiltrates with many parasites on the 7th and 15th days of infection. On the 30th day there was early granuloma formation. After 45 days the lesion was characterized by well defined epithelioid granuloma with multinuclear giant cells whose cytoplasm showed Schaumann bodies. Non-particulate antigenic material was present in the macrophage cytoplasm and between the lamellae of the Schaumann bodies. Granuloma formation has an important role for the control of infection at the inoculation site. The results indicate that dissemination of the infection must occur in the first 45 days, before granuloma formation has taken place.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Granuloma
/
Leishmaniose Visceral
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Int J Exp Pathol
Assunto da revista:
PATOLOGIA
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido