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Experimental models of autoimmune inflammatory ocular diseases.
Gasparin, Fabio; Takahashi, Beatriz Sayuri; Scolari, Mariana Ramos; Gasparin, Filipe; Pedral, Lycia Sampaio; Damico, Francisco Max.
Afiliação
  • Gasparin F; Universidade de São Paulo - USP, São Paulo (SP), Brazil. fgasparin@usp.br
Arq Bras Oftalmol ; 75(2): 143-7, 2012.
Article em En | MEDLINE | ID: mdl-22760810
Ocular inflammation is one of the leading causes of blindness and loss of vision. Human uveitis is a complex and heterogeneous group of diseases characterized by inflammation of intraocular tissues. The eye may be the only organ involved, or uveitis may be part of a systemic disease. A significant number of cases are of unknown etiology and are labeled idiopathic. Animal models have been developed to the study of the physiopathogenesis of autoimmune uveitis due to the difficulty in obtaining human eye inflamed tissues for experiments. Most of those models are induced by injection of specific photoreceptors proteins (e.g., S-antigen, interphotoreceptor retinoid-binding protein, rhodopsin, recoverin, phosducin). Non-retinal antigens, including melanin-associated proteins and myelin basic protein, are also good inducers of uveitis in animals. Understanding the basic mechanisms and pathogenesis of autoimmune ocular diseases are essential for the development of new treatment approaches and therapeutic agents. The present review describes the main experimental models of autoimmune ocular inflammatory diseases.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Uveíte / Células Fotorreceptoras de Vertebrados / Modelos Animais de Doenças Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Arq Bras Oftalmol Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Uveíte / Células Fotorreceptoras de Vertebrados / Modelos Animais de Doenças Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Arq Bras Oftalmol Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil