Pneumococcal disease: emergence of serotypes 19A and 7F following conjugate pneumococcal vaccination in a Mexican hospital.
J Infect Dev Ctries
; 6(6): 516-20, 2012 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-22706195
INTRODUCTION: Mexico was the country to initiate massive vaccination with heptavalent pneumococcal conjugate vaccine (PCV-7) in children. There is no information regarding pneumococcal invasive disease (PID) in children before and after implementation of PCV-7 in Mexico or elsewhere in Latin America. METHODOLOGY: During October 2005 to September 2010, active surveillance for pediatric PID was initiated at Tijuana General Hospital. Only culture-confirmed cases from sterile fluids were included in the study. Serotype identification was also performed. RESULTS: Twenty-eight pediatric PID cases were confirmed. Streptococcus pneumoniae was the main cause of pleural empyema (n = 13). It was also the second most common cause of confirmed bacterial meningitis (n = 10), followed by Neisseria meningitidis (n = ?), and the only cause of otomastoiditis with bacterial isolation (n = 5). Vaccine-associated serotypes decreased from 54% before PCV-7 introduction to the vaccination schedule, to only 5.6% after PCV-7 implementation. Serotypes 19A and 7F (47% and 33% respectively were predominant following PCV-7 vaccination. CONCLUSIONS: Serotype substitution in PID is present in the northern border of Mexico following PCV-7 vaccination in children.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Pneumocócicas
/
Streptococcus pneumoniae
/
Vacinas Pneumocócicas
Limite:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Infant
/
Male
País/Região como assunto:
Mexico
Idioma:
En
Revista:
J Infect Dev Ctries
Assunto da revista:
DOENCAS TRANSMISSIVEIS
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Itália