[Clinical and biochemical characterization of isoniazid-induced auto-antibodies]. / Caracterização clínico-laboratorial de auto-anticorpos induzidos por isoniazida.
Rev Paul Med
; 108(2): 57-60, 1990.
Article
em Pt
| MEDLINE
| ID: mdl-2259821
Isoniazid (INH) is one among many drugs capable of inducing autoantibodies and, in some cases, a lupus-like syndrome (LE). A longitudinal study was performed in 24 tuberculosis patients treated with INH to detect antibodies (A-AH) to total histones and fractions. Antinuclear antibodies were observed in two patients after treatment. Higher frequency of IgM-AH was also observed. IgM-AH binding to all fractions were observed in those serum samples exhibiting stronger ELISA reactivity. Conversely, binding to only H1 occurred when lower IgM-AH activity was tested. Correlations with clinical expressions of LE were not observed in the present study.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose Pulmonar
/
Imunoglobulina M
/
Histonas
/
Anticorpos Antinucleares
/
Isoniazida
Tipo de estudo:
Observational_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Pt
Revista:
Rev Paul Med
Ano de publicação:
1990
Tipo de documento:
Article
País de publicação:
Brasil