[Hydrogen potential of antibiotic solutions subjected to environmental conditions: a preliminary trial]. / Potencial hidrogeniônico de soluções de antibióticos submetidas a condições ambientais: ensaio preliminar.
Rev Esc Enferm USP
; 46(2): 311-9, 2012 Apr.
Article
em Pt
| MEDLINE
| ID: mdl-22576533
This experimental study was performed to assess the hydrogen potential (pH) of the antimicrobials ceftriaxone sodium, vancomycin hydrochloride, metronidazole, penicillin G potassium, and amikacin sulphate, following reconstitution, diluted with NaCl 0.9% (SF) and glucose solution 5% (GS), at eight different time intervals and under the normal daily conditions of lighting and temperature within the hospital unit (no air conditioning). The objective of this study was to verify the changes in the acid-base behavior of the solutions, which indicate chemical instability and can be associated with complications during intravenous therapy. Of the 186 analyzed pH values, there were no variations greater than 1.0 and no physical alterations visible to the naked eye. All solutions had a pH less than 7, and there were no significant differences for clinical practice regarding the diluent. The mean pH values after dilution with SF and GS for vancomycin hydrochloride, metronidazole, and amikacin sulphate are a risk factor for the development of intravenous complications due to their extreme acidity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estabilidade de Medicamentos
/
Hidrogênio
Tipo de estudo:
Risk_factors_studies
Idioma:
Pt
Revista:
Rev Esc Enferm USP
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil