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Antinociceptive and anti-inflammatory effects of ethanol extract from Vernonia polyanthes leaves in Rodents.
Dos Santos Temponi, Vanessa; Da Silva, Jucélia Barbosa; Alves, Maria Silvana; Ribeiro, Antônia; Pinho, José de Jesus Ribeiro Gomes de; Yamamoto, Célia Hitomi; Pinto, Miriam Aparecida Oliveira; Del-Vechio-Vieira, Glauciemar; De Sousa, Orlando Vieira.
Afiliação
  • Dos Santos Temponi V; Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
  • Da Silva JB; Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
  • Alves MS; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
  • Ribeiro A; Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora 36036-330, Brazil.
  • Pinho JJRG; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
  • Yamamoto CH; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
  • Pinto MAO; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
  • Del-Vechio-Vieira G; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
  • De Sousa OV; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
Int J Mol Sci ; 13(3): 3887-3899, 2012.
Article em En | MEDLINE | ID: mdl-22489187
The ethanol extract from Vernonia polyanthes leaves (EEVP) was investigated for antinociceptive and anti-inflammatory effects at the doses (p.o.) of 100, 200 and 400 mg/kg in animal models. The extract reduced the number of abdominal contortions by 16.75% and 31.44% at a dose of 200 and 400 mg/kg, respectively. The results obtained showed that EEVP exerted a significant antinociceptive effect in the two phases of formalin. The EEVP increased the reaction time on a hot plate at the doses of 100, 200 and 400 mg/kg after 90 min of treatment. The paw edema was reduced by EEVP at the doses of 100, 200 and 400 mg/kg after 4 h of application of carrageenan. Doses of 200 and 400 mg/kg, administered 4 h before the carrageenan injection, significantly reduced the exudate volume (29.25 and 45.74%, respectively) and leukocyte migration (18.19 and 27.95%, respectively). These results suggest that V. polyanthes can be an active source of substances with antinociceptive and anti-inflammatory activities.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Anti-Inflamatórios não Esteroides / Folhas de Planta / Vernonia / Analgésicos Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Anti-Inflamatórios não Esteroides / Folhas de Planta / Vernonia / Analgésicos Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça