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Interleukin-17 producing T helper cells are increased during natural Plasmodium vivax infection.
Bueno, Lilian Lacerda; Morais, Cristiane Guimarães; Lacerda, Marcus Vinícius; Fujiwara, Ricardo Toshio; Braga, Erika Martins.
Afiliação
  • Bueno LL; Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Acta Trop ; 123(1): 53-7, 2012 Jul.
Article em En | MEDLINE | ID: mdl-22476130
Recent evidences have demonstrated the importance of Th17 cells in host defense against infectious diseases. However, little is known about their role in parasitic infections. Here, we showed that uncomplicated acute vivax malaria induce a significant expansion of IL-17-producing CD4(+) T cells associated to a pro-inflammatory cytokine profile. Furthermore, we demonstrated a correlation between numbers of IL-17(+)CD4(+) T cells and circulating CD4(+) T-cells producing IFN-γ, IL-10 and TGF-ß. Finally, correlations between number of these cells and morbidity or parasitemia were not detected. Further studies are underway to investigate whether IL-17-producing CD4(+) T cells are critically involved in the immunity against Plasmodium vivax infection.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium vivax / Malária Vivax / Interleucina-17 / Células Th17 Limite: Adult / Humans / Middle aged Idioma: En Revista: Acta Trop Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium vivax / Malária Vivax / Interleucina-17 / Células Th17 Limite: Adult / Humans / Middle aged Idioma: En Revista: Acta Trop Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda