Interleukin-17 producing T helper cells are increased during natural Plasmodium vivax infection.
Acta Trop
; 123(1): 53-7, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22476130
Recent evidences have demonstrated the importance of Th17 cells in host defense against infectious diseases. However, little is known about their role in parasitic infections. Here, we showed that uncomplicated acute vivax malaria induce a significant expansion of IL-17-producing CD4(+) T cells associated to a pro-inflammatory cytokine profile. Furthermore, we demonstrated a correlation between numbers of IL-17(+)CD4(+) T cells and circulating CD4(+) T-cells producing IFN-γ, IL-10 and TGF-ß. Finally, correlations between number of these cells and morbidity or parasitemia were not detected. Further studies are underway to investigate whether IL-17-producing CD4(+) T cells are critically involved in the immunity against Plasmodium vivax infection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium vivax
/
Malária Vivax
/
Interleucina-17
/
Células Th17
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Acta Trop
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Holanda