Your browser doesn't support javascript.
loading
Interaction between endothelial nitric oxide synthase gene polymorphisms (-786T>C, 894G>T and intron 4 a/b) and cardiovascular risk factors in acute coronary syndromes.
da Costa Escobar Piccoli, Jacqueline; Manfredini, Vanusa; Hamester, Fernanda Irma; Bandinelli, Josiane Bettim; Turkienicz, Ilan Maltz; Chies, José Artur Bogo; Peres, Alessandra; Bodanese, Luiz Carlos; Bogo, Maurício Reis.
Afiliação
  • da Costa Escobar Piccoli J; Universidade Federal do Pampa, Campus Uruguaiana-RS, Brazil. jcepiccoli@yahoo.com.br
Arch Med Res ; 43(3): 205-11, 2012 Apr.
Article em En | MEDLINE | ID: mdl-22475779
BACKGROUND AND AIMS: Endothelial rupture of coronary plaque can represent the pathomorphological substratum of acute coronary syndrome (ACS). Polymorphisms in the NOS3 gene (eNOS) -786T>C, 894G>T and intron 4 a/b VNTR can be associated with a higher susceptibility for ACS. The present study is focused on the investigation of the interaction of these polymorphisms and cardiovascular risk factors in 135 patients with ACS and 115 control subjects. METHODS: Case-control study where the allele and genotype frequencies of the polymorphisms -786T> C, 894G> T and intron 4 VNTR of the gene encoding eNOS were determined by PCR-RFLP associated with cardiovascular risk factors. RESULTS: An association of the 894TT genotype and 894GT+GG (OR 1.4; 95% CI 1.0-1.8) in ACS has been observed. Subjects without dyslipidemia and intron 4 a/b genotype present a lower chance for ACS development, whereas subjects without diabetes and 894TT genotype show a higher risk for ACS (OR 1.7; 95% CI 1.2-2.3). In patients without dyslipidemia, the 894GG genotype presented a tendency to behave as a protector factor against ACS. Also, the 894GG genotype has been a protective factor for ACS in females (OR 0.5; CI 95% 0.2-0.9). CONCLUSIONS: Our results suggest that eNOS polymorphisms may be an additional risk factor in development of ACS.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óxido Nítrico Sintase Tipo III / Síndrome Coronariana Aguda Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Med Res Assunto da revista: MEDICINA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óxido Nítrico Sintase Tipo III / Síndrome Coronariana Aguda Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Med Res Assunto da revista: MEDICINA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos