[Total prostatic specific antigen levels among subjects exposed and not exposed to arsenic in drinking water]. / Niveles séricos del antígeno prostático específico en varones expuestos y no expuestos al arsénico en el agua de bebida en Tucumán, Argentina.
Rev Med Chil
; 139(12): 1581-7, 2011 Dec.
Article
em Es
| MEDLINE
| ID: mdl-22446704
BACKGROUND: There is an association between arsenic exposure and prostatic cancer mortality. AIM: To analyze and to compare the serum levels of total prostatic specific antigEn (TPSA) in asymptomatic men of a rural zone, exposed and not exposed to high concentrations of arsenic (As) in drinking water. MATERIAL AND METHODS: The study included 161 men that were subjected to a clinical evaluation, serum TPSA determination and a trans rectal ultrasonography. Exposed and non-exposed subjects were divided in groups GA, GB and GC according to TPSA levels (<4 ng/ml, 4.1-10 ng/ml and >10.1 ng/ml respectively). RESULTS: Exposed and non-exposed subjects had similar TPSA levels. Among exposed subjects, 88.2, 8,8 and 3% were ascribed to groups GA, GB and GC respectively. The figures for non-exposed subjects were 90. 6, 6,3 and 3,1%. The area under the receiver operating characteristic (ROC) curve for TPSA in exposed and non-exposed subjects was 0.64 (95% confidence intervals (CI) 0.40-0.9) and 0.71 (95% CI 0.6-0.8) respectively. CONCLUSIONS: No differences in TPSA levels between subjects exposed and non-exposed to arsenic were observed in this study.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Água Potável
/
Antígeno Prostático Específico
/
Intoxicação por Arsênico
/
Exposição Ambiental
Tipo de estudo:
Prognostic_studies
Limite:
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do sul
/
Argentina
Idioma:
Es
Revista:
Rev Med Chil
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Chile