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Gestational and postnatal protein deficiency affects postnatal development and histomorphometry of liver, kidneys, and ovaries of female rats' offspring.
Almeida, Fernanda R C L; Silva, Gerluza A B; Fiúza, Aparecida T L; Chianca, Deoclécio A; Ferreira, Anderson J; Chiarini-Garcia, Hélio.
Afiliação
  • Almeida FR; Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. falmeida@icb.ufmg.br
Appl Physiol Nutr Metab ; 37(2): 293-300, 2012 Apr.
Article em En | MEDLINE | ID: mdl-22436076
Pre- and postnatal protein deficiency may lead to decreased foetal intra-uterine development and postnatal growth, which is common in developing countries. The present study aimed to investigate the consequences of a low-protein intake during gestation and postnatally on adult female rats' offspring. Female rats were given either a control or a protein-deficient diet throughout the gestation and lactation periods. A subset of females was killed at day 20 of pregnancy for foetal and placental measurements. Another subset of females farrowed and the number, length, and weight of the offspring were measured. After weaning, the offspring received the same diet as their dams until 70 days of age. They were sacrificed, and some organs were weighed and collected for histomorphometrical analyses. Placental weight and size and foetal weight were lower in protein-deficient dams. The weight and length of pups at birth were also lower in the deficient group. The organs to body weight ratio were higher in the deficient animals at 70 days of age. The protein-deficient female offspring had a smaller ovarian area, greater numbers of primordial follicles and developing follicles per square millimetres of ovarian cortex, and no corpora lutea. The liver showed smaller nuclear diameter of the hepatocytes and height of the hepatocytes cords. The kidneys showed smaller cortical area with reduced glomerular number and diameter. These results provide the first evidence of the histomorphological changes of the association between gestational and postnatal protein deficiency in female rats' offspring.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deficiência de Proteína / Proteínas / Rim / Fígado Limite: Animals / Pregnancy Idioma: En Revista: Appl Physiol Nutr Metab Assunto da revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / MEDICINA ESPORTIVA / METABOLISMO Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deficiência de Proteína / Proteínas / Rim / Fígado Limite: Animals / Pregnancy Idioma: En Revista: Appl Physiol Nutr Metab Assunto da revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / MEDICINA ESPORTIVA / METABOLISMO Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá