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Effect of N-acetylcysteine on lung injury induced by skeletal muscle ischemia-reperfusion. Histopathlogical study in rat model.
Sotoudeh, Amir; Takhtfooladi, Mohammad Ashrafzadeh; Jahanshahi, Amirali; Asl, Adel Haghighi Khiabanian; Takhtfooladi, Hamed Ashrafzadeh; Khansari, Mohammadreza.
Afiliação
  • Sotoudeh A; Faculty of Veterinary Science, Kahnooj Branch, Islamic Azad University, Kerman, Iran.
Acta Cir Bras ; 27(2): 168-71, 2012 Feb.
Article em En | MEDLINE | ID: mdl-22378373
PURPOSE: To investigate whether N-acetylcysteine, a free radicals scavenger has a protective effect against lung injury as a remote organ after skeletal muscle ischemia-reperfusion. METHODS: Twenty Wistar male rats were divided randomly into two experimental groups: group ischemia-reperfusion (group I) and group ischemia-reperfusion +N-acetylcysteine (group II). All animals were undergone two hours of ischemia by occlusion femoral artery and 24h of reperfusion. Before clamped the femoral artery, 250 IU heparin was administered via the jugular vein to prevent clotting. Rats that were treated with N-acetylcysteine given IV at a dose of 150 mgkg(-1), immediately before reperfusion. After 24h of reperfusion, animals were euthanized and left lung harvested for histopathological analysis under light microscopy. RESULTS: In the group I, tissues showed histological changes with intra-alveolar edema, intra-alveolar hemorrhage and neutrophilic infiltration. Histopathologically, there was a significant difference (P = 0.005) between two groups. CONCLUSION: Administration of N-acetylcysteine treatment significantly decreased lung injury induced by skeletal muscle ischemia reperfusion according to histological findings.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcisteína / Traumatismo por Reperfusão / Sequestradores de Radicais Livres / Músculo Esquelético / Modelos Animais de Doenças / Lesão Pulmonar Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcisteína / Traumatismo por Reperfusão / Sequestradores de Radicais Livres / Músculo Esquelético / Modelos Animais de Doenças / Lesão Pulmonar Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil