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Plasma cortisol in first episode drug-naïve mania: differential levels in euphoric versus irritable mood.
Valiengo, Leandro L; Soeiro-de-Souza, Márcio G; Marques, Andrea H; Moreno, Doris H; Juruena, Mário F; Andreazza, Ana Cristina; Gattaz, Wagner F; Machado-Vieira, Rodrigo.
Afiliação
  • Valiengo LL; Laboratory of Neuroscience, LIM-27, Institute and Department of Psychiatry, University of São Paulo, SP, Brazil.
J Affect Disord ; 138(1-2): 149-52, 2012 Apr.
Article em En | MEDLINE | ID: mdl-22305430
BACKGROUND: Dysregulation of HPA axis has been widely described in subjects with bipolar disorder (BD), including changes in cortisol levels during mood episodes and euthymia. However, most of the studies were done with medicated BD patients with variable length of illness, which was shown to interfere on peripheral cortisol levels. Therefore, the present study aims to evaluate plasma cortisol levels in drug-naïve BD subjects during the first manic episode, as well as investigate the relationship between plasma cortisol levels and manic symptomatology. METHODS: Twenty-six drug-naïve patients were enrolled meeting criteria for a first manic episode in bipolar I disorder. Severity of mania was assessed using the Young Mania Rating Scale (YMRS). The control group included 27 healthy subjects matched by age and gender. Cortisol was quantified using a direct radioimmunoassay. RESULTS: Plasma cortisol levels were decreased during first manic episode compared to healthy controls. Higher cortisol levels were positively associated with the presence of irritability (dysphoria), while elated mania showed lower cortisol levels compared to controls. LIMITATION: Data including larger samples are lacking. CONCLUSION: Higher cortisol in dysphoric mania compared to predominantly elated/euphoric mania may indicate a clinical and neurobiological polymorphic phenomenon, potentially involving a higher biological sensitivity to stress in the presence of irritable mood. The present findings highlight the importance to add a dimensional approach to the traditional categorical diagnosis for future neurobiological studies in BD.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Hidrocortisona Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Humans Idioma: En Revista: J Affect Disord Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Hidrocortisona Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Humans Idioma: En Revista: J Affect Disord Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda