Suppression of mouse IgE response by immune complexes.
J Allergy Clin Immunol
; 86(4 Pt 1): 496-502, 1990 Oct.
Article
em En
| MEDLINE
| ID: mdl-2229811
The effect of antibodies alone or complexed to antigen on an IgE response was compared in mice immunized with a low dose of antigen. The results demonstrated that immune complexes (ICs) at equivalence were more efficient than antibodies in promoting a suppression of this response when they were injected simultaneously or before, but not after, the antigen. This effect was dose dependent, antigen specific, and long lasting. Furthermore, only isologous ICs were suppressive. ICs prepared with IgG1 antibodies were more effective than ICs prepared with IgG2. Digestion of the Fc fragment of the antibody eliminated completely the suppressive action of antibodies alone, but not of ICs. These results indicate that, whereas an Fc-dependent mechanism is responsible for the effect of antibodies, an additional mechanism is also operating in suppression induced by ICs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina E
/
Tolerância Imunológica
/
Complexo Antígeno-Anticorpo
Limite:
Animals
Idioma:
En
Revista:
J Allergy Clin Immunol
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos