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Cardiac function in dogs with chronic Chagas cardiomyopathy undergoing autologous stem cell transplantation into the coronary arteries.
Sousa, Marlos G; Paulino-Junior, Daniel; Pascon, João P E; Pereira-Neto, Gláucia B; Carareto, Roberta; Champion, Tatiana; Camacho, Aparecido A.
Afiliação
  • Sousa MG; The Federal University of Tocantins State (UFT), College of Veterinary Medicine and Animal Science, Tocantins, Brazil. john.ellis@usask.ca
Can Vet J ; 52(8): 869-74, 2011 Aug.
Article em En | MEDLINE | ID: mdl-22294793
This study assessed the effects of a single intracoronary injection of autologous stem cells on the cardiac function of dogs with Chagas cardiomyopathy. Bone-marrow-derived stem cells were delivered into the right and left coronary arteries of 5 mature dogs with mildly compromised cardiac function due to chronic Chagas cardiomyopathy. Blood pressure and electrocardiographic and echocardiographic parameters were recorded at monthly intervals for 6 mo in the 3 dogs that survived. Although no changes were observed in the electrocardiogram and blood pressure, there was a significant increase in peak velocity of aortic flow 3 mo after stem cell transplantation. Pre-ejection period, isovolumic relaxation time, and the Tei index of myocardial performance were reduced significantly 4 mo after the procedure. All significant changes persisted to the end of the study. The results suggest that the transplantation of autologous bone-marrow-derived stem cells into the coronary arteries of dogs with Chagas cardiomyopathy may have a beneficial effect but the small number of dogs studied was a limitation.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia Chagásica / Transplante de Células-Tronco / Doenças do Cão / Coração Limite: Animals Idioma: En Revista: Can Vet J Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia Chagásica / Transplante de Células-Tronco / Doenças do Cão / Coração Limite: Animals Idioma: En Revista: Can Vet J Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá