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Albendazole versus metronidazole in the treatment of adult giardiasis: a randomized, double-blind, clinical trial.
Cañete, Roberto; Rodríguez, Pablo; Mesa, Lumey; Brito, Katia; Prior, Ada; Guilhem, Dirce; Novaes, M R C G.
Afiliação
  • Cañete R; Cuban Institute of Gastroenterology, Havana City, Cuba. roberto.villafranca@infomed.sld.cu
Curr Med Res Opin ; 28(1): 149-54, 2012 Jan.
Article em En | MEDLINE | ID: mdl-22114904
BACKGROUND: Albendazole (ABZ) is a benzimidazole carbamate compound currently in use for human medical practice against enterobiasis and soil-transmitted helminthiasis (STH); However, its spectrum of activity is broad and goes beyond these infections. OBJECTIVE: This study compares the efficacy and safety of ABZ versus metronidazole (MTZ) in human giardiasis. RESEARCH DESIGN AND METHODS: A randomized, double-blind, clinical trial was carried out at the Centre of Hygiene, Epidemiology and Microbiology in Matanzas City, Cuba. Adult patients with confirmed symptomatic G. duodenalis mono-infection were randomly assigned to receive either ABZ [400 mg daily (n = 75)] or MTZ [250 mg t.i.d. (n = 75)], both for 5 days. Follow-up fecal samples were obtained at 3, 5, 7 days after treatment end. RESULTS: The efficacy was similar for both treatment groups: ABZ (82.6%) and MTZ (85.3%); p > 0.05. Side-effects including bitter taste, headache, vomiting and dizziness were significantly higher in the MTZ group. Abdominal pain was significantly higher in ABZ group. CONCLUSION: ABZ was found as effective as MTZ in the treatment of G. duodenalis infections in adult patients from Cuba and could be a useful drug in areas where co-infection with STH infections is common.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Albendazol / Giardíase / Metronidazol Tipo de estudo: Clinical_trials Limite: Adult / Humans País/Região como assunto: Caribe / Cuba Idioma: En Revista: Curr Med Res Opin Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Cuba País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Albendazol / Giardíase / Metronidazol Tipo de estudo: Clinical_trials Limite: Adult / Humans País/Região como assunto: Caribe / Cuba Idioma: En Revista: Curr Med Res Opin Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Cuba País de publicação: Reino Unido