[If no-acid, no-heartburn? New physiopathological mechanisms of the gastroesophageal reflux disease]. / ¿Si no hay ácido no hay pirosis? Nuevos mecanismos fisiopatológicos de la enfermedad por reflujo gastroesofágico.
Rev Gastroenterol Mex
; 76(3): 237-46, 2011.
Article
em Es
| MEDLINE
| ID: mdl-22041313
The role of acid is very well established in the pathogenesis of gastroesophageal reflux disease (GERD). In the current era of frequent use of proton pump inhibitors, we are seeing increasing numbers of patients with symptoms that are refractory to acid suppression. Recent studies suggest that in patients being treated with proton pump inhibitors, non-acid reflux (composed of buffered gastric contents), esophageal hypersensitivity, esophageal motor dysfunction and psychological comorbidity can cause persistent symptoms. Concepts surrounding possible pathogenetic mechanisms leading to heartburn as a result of nonacid reflux and other mechanisms are explored, and potential treatments for this type of reflux are outlined in this review.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Refluxo Gastroesofágico
/
Azia
Limite:
Humans
Idioma:
Es
Revista:
Rev Gastroenterol Mex
Ano de publicação:
2011
Tipo de documento:
Article
País de publicação:
México