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Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis.
Nogueira Neto, João; Cavalcante, Frederico Lucas Lima Paiva; Carvalho, Rafael Antonio Freire; Rodrigues, Taciana Gabrielle Pinheiro de Moura; Xavier, Mariana Santana; Furtado, Pablo Gustavo Ribeiro; Schor, Eduardo.
Afiliação
  • Nogueira Neto J; Unit of Endometriosis and Surgical Laboratory, HU-UFMA, Maranhao,Brazil. j.nogueira.n@uol.com.br
Acta Cir Bras ; 26 Suppl 2: 15-9, 2011.
Article em En | MEDLINE | ID: mdl-22030809
PURPOSE: Evaluate the histological changes in parenchyma's epithelial layer of the uterus and ovarian of rats with induced endometriosis, treated with Uncaria tomentosa extract. METHODS: 29 rats with experimental endometriosis, were selected and divided in three groups: The uncaria group received 32 mg/ml of Uncaria tomentosa extract, 1 ml administered daily and the placebo group received 1 ml of saline 0.9% per day, during for 14 days (both groups); the leuprolide group received leuprolide acetate 1mg/kg body weight applied single subcutaneous dose. In the 15th day of treatment the uterine horn and ovaries were removed for histopathological analysis. RESULTS: The uncaria group presented nine samples (90%) with immature ovarian follicles, whereas the placebo group did not present any case and in the leuprolide group there were eight rats (88%) with the same change. The placebo group showed mature corpus luteum in all animals, occurring less frequent in uncaria (10%) and leuprolide (22%) groups. The uterine epithelium showed weak proliferative in nine (90%) samples of the uncaria group, in two (20%) animals in the placebo group and seven (77.8%) rats in the leuprolide group. CONCLUSIONS: The findings suggest that Uncaria tomentosa has contraceptive effect.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Anticoncepcionais / Unha-de-Gato / Endometriose / Fitoterapia Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Anticoncepcionais / Unha-de-Gato / Endometriose / Fitoterapia Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil