Immunoexpression of TNF-α and TGF-ß in central and peripheral giant cell lesions of the jaws.
J Oral Pathol Med
; 41(2): 194-9, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-21913991
BACKGROUND: Peripheral giant cell lesion (PGCL) is a reactive process associated with a local irritating factor that shows low recurrence after treatment, especially if the irritating factor is eliminated. On the other hand, central giant cell lesion (CGCL) presents a variable clinical behavior ranging from slow and asymptomatic growth without recurrence to rapid, painful and recurrent growth. Our aim was to compare the immunoexpression of tumor necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-ß) in CGCL and PGCL. METHODS: Twenty CGCL and 20 PGCL were selected for analysis of the immunoexpression of TNF-α and TGF-ß in multinucleated giant cells (MGC) and mononucleated cells (MC). RESULTS: The PGCL showed lightly higher expression of TNF-α than CGCL. In comparison with PGCL, the CGCL showed higher expression of TGF-ß in MC and MGC (P < 0.05) and in total cells (P < 0.05). Significant positive correlation was found between expressions of TGF-ß and TNF-α in CGCL (P < 0.05). CONCLUSIONS: Our results suggest that, in CGCL, coordinated interactions between TGF-ß and TNF-α may be important for osteoclastogenesis and bone resorption. PGCL occasionally cause bone resorption but to a lower extent, a fact that might be explained by the lower expression of TGF-ß in these lesions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Granuloma de Células Gigantes
/
Doenças Maxilomandibulares
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Fator de Crescimento Transformador beta
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Fator de Necrose Tumoral alfa
Limite:
Humans
Idioma:
En
Revista:
J Oral Pathol Med
Assunto da revista:
ODONTOLOGIA
/
PATOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Dinamarca