Low frequency of Toll-like receptors 2 and 4 gene polymorphisms in Mexican patients and their association with type 2 diabetes.
Int J Immunogenet
; 38(6): 519-23, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-21902816
Type 2 diabetes (T2D) is characterized by a chronic low-grade inflammatory state. SNP in Toll-like receptor (TLR) genes has been associated with impaired inflammatory response. We genotyped the TLR4/D299G, TLR4/T399I and TLR2/R753Q polymorphisms. Low frequency was found with no association with T2D, nevertheless the TLR2 SNP was associated with lower levels in HDL-cholesterol values.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Diabetes Mellitus Tipo 2
/
Receptor 2 Toll-Like
/
Receptor 4 Toll-Like
/
Estudos de Associação Genética
/
Frequência do Gene
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Int J Immunogenet
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
GENETICA
Ano de publicação:
2011
Tipo de documento:
Article
País de publicação:
Reino Unido