Endothelial nitric oxide-dependent vasorelaxant effect of isotirumalin, a dihydroflavonol from Derris urucu, on the rat aorta.
Biol Pharm Bull
; 34(9): 1499-500, 2011.
Article
em En
| MEDLINE
| ID: mdl-21881240
The present work aimed to investigate the vasorelaxant effect of isotirumalin, a dihydroflavonol isolated from Derris urucu (Leguminosae). The vasorelaxant effect of isotirumalin was investigated in the rat aorta, in the presence and in the absence of a functional endothelium. The production of nitric oxide (NO) induced by isotirumalin was measured simultaneously with its vasorelaxation using carbon microsensors. In endothelium-intact aortic rings, isotirumalin induced a concentration-dependent vasodilator effect the concentration required to produce 30% of relaxation (pIC30=4.84±0.24) that was abolished in endothelium-denuded aortic rings or in the presence of Nω-nitro-L-arginine-methyl-ester (L-NAME; 300 µM). In addition, isotirumalin (100 µM) induced a simultaneous and significant increase on NO production, which was blunted in the presence of L-NAME. The present results demonstrate that isotirumalin is a vasodilator in the rat aorta and act by a mechanism dependent on the presence of a functional endothelium and on NO production.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aorta
/
Vasodilatadores
/
Endotélio Vascular
/
Derris
/
Flavonóis
/
Óxido Nítrico
Limite:
Animals
Idioma:
En
Revista:
Biol Pharm Bull
Assunto da revista:
BIOQUIMICA
/
FARMACOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Japão