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Impact of rotavirus vaccination on diarrhoea mortality and hospital admissions in Brazil.
Gurgel, Ricardo Q; Ilozue, Chinenye; Correia, Jailson B; Centenari, Chiara; Oliveira, Sandala M T; Cuevas, Luis E.
Afiliação
  • Gurgel RQ; Federal University of Sergipe, Aracaju, Brazil. ricardoqg@infonet.com.br
Trop Med Int Health ; 16(9): 1180-4, 2011 Sep.
Article em En | MEDLINE | ID: mdl-21749584
OBJECTIVE: To analyse the data reported by the national surveillance system of Brazil, including data on diarrhoea mortality and hospital admissions before and after rotavirus vaccine introduction, and evaluate the impact of its widespread use under operational conditions. METHOD: Retrospective analysis of routinely collected data was reported by several surveillance systems of Brazil, comprising an 8-year period of all diarrhoea-related hospitalisations and deaths in children <5 years old (2002-2009). Linear regressions were used to compare trends of diarrhoea hospitalisations and deaths before and after vaccine introduction (2002-2005 vs. 2006-2009). RESULTS: There was a long-term reduction in hospitalisations that preceded the introduction of the vaccine. This reduction was more marked in <1-year-old than in 1- to 4-year-old children. All-cause diarrhoea hospitalisations decreased further after vaccine introduction and the decrease was larger in <1-year-old (-35.6%) than in 1- to 4-year-old children (-12.3%). The number of deaths was decreasing before vaccine introduction, and the decrease also accelerated after vaccine introduction, with deaths halving in <1-year-old and decreasing by 32.9% in 1- to 4-year-old children. The linear relationships between hospitalisations and deaths were statistically different before and after vaccine introduction. CONCLUSIONS: The data demonstrate a decreasing trend in all-cause diarrhoea-related hospitalisations and deaths in children <5 years of age. These reductions were steeper between 2006 and 2009, highlighting the potential beneficial effect of the rotavirus vaccine associated with all-cause diarrhoeal disease.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Vacinas contra Rotavirus / Diarreia Tipo de estudo: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Trop Med Int Health Assunto da revista: MEDICINA TROPICAL / SAUDE PUBLICA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Vacinas contra Rotavirus / Diarreia Tipo de estudo: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Trop Med Int Health Assunto da revista: MEDICINA TROPICAL / SAUDE PUBLICA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido