Inhibition of HIV-1 reverse transcriptase, toxicological and chemical profile of Calophyllum brasiliense extracts from Chiapas, Mexico.
Fitoterapia
; 82(7): 1027-34, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21723379
Calophyllum species are sources of calanolides, which inhibit human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). The hexane extract of the leaves from C. brasiliense collected in Soconusco, State of Chiapas, Mexico, analyzed by HPLC showed to contain apetalic acid, calanolides B, and C. It showed potent anti-HIV-1 RT inhibition (IC(50)=20.2 µg/ml), but was not toxic in mice (LD(50)=1.99 g/kg). The histological study of the mice treated at the highest dose revealed no alteration on hepatocytes, and an increase in the number of spleen megakaryocytes. These results suggest this extract is suitable to continue studies for developing a phytodrug against HIV-1.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Inibidores da Transcriptase Reversa
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Calophyllum
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Piranocumarinas
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Transcriptase Reversa do HIV
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Isoflavonas
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Fitoterapia
Limite:
Animals
/
Humans
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Male
País/Região como assunto:
America do sul
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Brasil
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Mexico
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2011
Tipo de documento:
Article
País de publicação:
Holanda