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Characteristics and comorbidity of ADHD sib pairs in the Central Valley of Costa Rica.
Schuler, Jovita; Weiss, Nicholas T; Chavira, Denise A; McGough, James J; Berrocal, Monica; Sheppard, Brooke; Vaglio, Evelyn; Fournier, Eduardo; Herrera, Luis Diego; Mathews, Carol A.
Afiliação
  • Schuler J; Psychology Institute, University of Zurich, Zurich, Switzerland.
Compr Psychiatry ; 53(4): 379-86, 2012 May.
Article em En | MEDLINE | ID: mdl-21696714
BACKGROUND: While genetic epidemiological studies demonstrate a substantial degree of genetic predisposition for attention-deficit/hyperactivity disorder (ADHD), they also suggest that the genetics are complex and may differ between populations or ethnic groups. OBJECTIVE: This study describes the phenomenology of siblings with ADHD from the genetically isolated population of the Central Valley of Costa Rica. METHODS: Rates of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)-defined ADHD subtypes and comorbid conditions were calculated in a sample of 157 ADHD-affected children (probands and siblings) recruited for genetic studies using standardized approaches. Sib-sib comparisons and logistic regressions were conducted to identify significant patterns of concordance. RESULTS: Combined-type ADHD (69.5%) was the most common subtype among probands, followed by the inattentive (27.4%), and hyperactive-impulsive (3.2%) subtypes. Anxiety disorders were prevalent (55.9%), as were disruptive behavior disorders (30.9%) and Tourette disorder (17.0%). Probands and siblings showed high sib-sib concordance for anxiety disorders. CONCLUSIONS: ADHD in Costa Rica is similar in clinical and demographic characteristics to ADHD seen in other parts of the world, although the rates of co-occurring psychiatric disorders differ somewhat from those previously reported in Latin American samples. Comorbid anxiety is prevalent, with high rates of sib-sib concordance, and may represent a distinct, homogeneous subgroup suitable for genetic studies.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno do Deficit de Atenção com Hiperatividade / Transtornos Mentais Tipo de estudo: Diagnostic_studies / Guideline / Prevalence_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male País/Região como assunto: America central / Costa rica Idioma: En Revista: Compr Psychiatry Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Suíça País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno do Deficit de Atenção com Hiperatividade / Transtornos Mentais Tipo de estudo: Diagnostic_studies / Guideline / Prevalence_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male País/Região como assunto: America central / Costa rica Idioma: En Revista: Compr Psychiatry Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Suíça País de publicação: Estados Unidos