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Physical therapy intervention (PTI) increases plasma brain-derived neurotrophic factor (BDNF) levels in non-frail and pre-frail elderly women.
Coelho, F M; Pereira, D S; Lustosa, L P; Silva, J P; Dias, J M D; Dias, R C D; Queiroz, B Z; Teixeira, A L; Teixeira, M M; Pereira, L S M.
Afiliação
  • Coelho FM; Departamento de Fisioterapia da Escola de Educacao Fisica, Fisioterapia e Terapia Ocupacional, Universidade Federal de Minas Gerais, Avenida Antonio Carlos, 6627 Pampulha, 31270-901 Belo Horizonte, Minas Gerais, Brazil. fematoscoelho@gmail.com
Arch Gerontol Geriatr ; 54(3): 415-20, 2012.
Article em En | MEDLINE | ID: mdl-21684022
Biomarkers are important factors in the identification of the frail elderly (higher risk of developing disease) and in assessing the impact of PTI. On the other hand, BDNF has been related to neuroprotection in a series of central nervous system diseases in older age. The levels of BDNF in groups of elderly women classified according to Fried phenotype (non-frail and pre-frail) were compared. We assessed the impact of a PTI on BDNF levels. A convenience sample of 48 elderly women was randomly selected. The PTI group was composed by 20 elderly women selected from this group. Plasma neurotrophic factors, such as BDNF, glial-derived neutrophic factor (GDNF), and nerve growth factor (NGF) were measured by enzyme-linked immunosorbent assay (ELISA). Timed-up-and-go (TUG) test, hand-grip and work/body weight were evaluated before and after the intervention. Plasma concentrations of BDNF were significantly higher in non-frail in comparison to pre-frail elderly women. After the PTI, higher levels of BDNF were found in elderly women (before 351±68 pg/ml and after 593±79 pg/ml; p<0.001). Both groups had an increase in BDNF levels after the PTI. The low levels of BDNF in pre-frail elderly women suggest that this neurotrophic factor may be a key pathophysiological mediator in the syndrome of frailty. The fact that PTI increased BDNF levels in both groups suggests that it may be possible to modify this phenotype.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Idoso Fragilizado / Modalidades de Fisioterapia / Fator Neurotrófico Derivado do Encéfalo Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Aged / Female / Humans / Middle aged Idioma: En Revista: Arch Gerontol Geriatr Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Idoso Fragilizado / Modalidades de Fisioterapia / Fator Neurotrófico Derivado do Encéfalo Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Aged / Female / Humans / Middle aged Idioma: En Revista: Arch Gerontol Geriatr Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda