The effect of calcium supplementation on blood lead levels in Nigerian children.
J Pediatr
; 159(5): 845-850.e1, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21665223
OBJECTIVE: To determine whether calcium supplementation alters the risk of lead toxicity. STUDY DESIGN: Children aged 12-18 months from 3 communities in Nigeria were assigned to receive daily calcium supplementation, as either calcium carbonate (400 mg) or ground dried fish (529 ± 109 mg), or placebo. All children received 2500 IU of vitamin A. Levels of blood lead, calcium, and vitamin D metabolites were measured at baseline and after 12-18 months (n = 358). RESULTS: The mean (± SD) baseline lead level was 11.1 ± 7.8 µg/dL (range, 1-43 µg/dL; median, 9 µg/dL); 44.7% of subjects had a lead level >10 µg/dL. After 12-18 months, the mean lead level was 8.1 ± 6.3 µg/dL (range, 1-48 µg/dL; median, 6 µg/dL), with 22.6% with a level >10 µg/dL. Lead levels at baseline varied among communities (P = .01) and were higher in children who used eye cosmetics or lived near a lead-acid battery melter (both P < .001). In a multiple regression model, the decrease in blood lead level was predicted by age, baseline lead level, and time of final lead value at 12-18 months (R(2) = 31%), but not by calcium supplementation (P = .98). CONCLUSIONS: Lead toxicity is common in Nigerian children, but calcium supplementation does not affect blood lead levels.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbonato de Cálcio
/
Alimentos Formulados
/
Suplementos Nutricionais
/
Produtos Pesqueiros
/
Chumbo
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
J Pediatr
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Estados Unidos