An insect growth inhibitor--lufenuron--enhances albendazole activity against hydatid cyst.
Vet Parasitol
; 181(2-4): 341-4, 2011 Sep 27.
Article
em En
| MEDLINE
| ID: mdl-21592667
The aim of this work was to evaluate the potential of lufenuron, a benzylphenylurea with ability to interfere with the formation of insect exoskeleton, as a therapeutic drug for larval echinococcosis (hydatid disease). For this purpose lufenuron, alone or in combination with albendazole, was administered to CD1 mice bearing Echinococcus granulosus hydatid cysts in the peritoneal cavity. Neither of the drugs alone was able to exert parasiticidal effects. However, in combination with albendazole, lufenuron reduced the growth of cysts (30-40% in cyst diameter respect to control, p<0.05). This effect was associated with ultrastructural alterations of the hydatid cyst wall and a reduction of the content of myo-inositol-hexakisphosphate, the major component of the electron dense granules of the laminated layer. Overall, this work provides evidence that lufenuron could represent a useful compound for the use in chemotherapy against larval echinococcosis, by enhancing albendazole parasiticidal activity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzamidas
/
Albendazol
/
Equinococose
/
Anti-Helmínticos
Limite:
Animals
Idioma:
En
Revista:
Vet Parasitol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Uruguai
País de publicação:
Holanda