Semantic dementia versus nonfluent progressive aphasia: neuropsychological characterization and differentiation.
Alzheimer Dis Assoc Disord
; 26(1): 36-43, 2012.
Article
em En
| MEDLINE
| ID: mdl-21552095
BACKGROUND: Early progressive nonfluent aphasia (PNFA) may be difficult to differentiate from semantic dementia (SD) in a nonspecialist setting. There are descriptions of the clinical and neuropsychological profiles of patients with PNFA and SD but few systematic comparisons. METHOD: We compared the performance of groups with SD (n=27) and PNFA (n=16) with comparable ages, education, disease duration, and severity of dementia as measured by the Clinical Dementia Rating Scale on a comprehensive neuropsychological battery. Principal components analysis and intergroup comparisons were used. RESULTS: A 5-factor solution accounted for 78.4% of the total variance with good separation of neuropsychological variables. As expected, both groups were anomic with preserved visuospatial function and mental speed. Patients with SD had lower scores on comprehension-based semantic tests and better performance on verbal working memory and phonological processing tasks. The opposite pattern was found in the PNFA group. CONCLUSIONS: Neuropsychological tests that examine verbal and nonverbal semantic associations, verbal working memory, and phonological processing are the most helpful for distinguishing between PNFA and SD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Afasia Primária Progressiva não Fluente
/
Degeneração Lobar Frontotemporal
/
Doença de Alzheimer
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Alzheimer Dis Assoc Disord
Assunto da revista:
NEUROLOGIA
/
PSIQUIATRIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos