Guns, germs and dogs: On the origin of Leishmania chagasi.
Infect Genet Evol
; 11(5): 1091-5, 2011 Jul.
Article
em En
| MEDLINE
| ID: mdl-21511057
The evolutionary history of Leishmania chagasi, the aetiological agent of visceral leishmaniasis in South America has been widely debated. This study addresses the problem of the origin of L. chagasi, its timing and demography with fast evolving genetic markers, a suite of Bayesian clustering algorithms and coalescent modelling. Here, using 14 microsatellite markers, 450 strains from the Leishmania donovani complex, we show that the vast majority of the Central and South American L. chagasi were nested within the Portuguese Leishmania infantum clade. Moreover, L. chagasi allelic richness was half that of their Old World counterparts. The bottleneck signature was estimated to be about 500 years old and the settlement of L. chagasi in the New World, probably via infected dogs, was accompanied by a thousand-fold population decrease. Visceral leishmaniasis, lethal if untreated, is therefore one more disease that the Conquistadores brought to the New World.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leishmania
/
Leishmaniose Visceral
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
País/Região como assunto:
America central
/
America do sul
Idioma:
En
Revista:
Infect Genet Evol
Assunto da revista:
BIOLOGIA
/
DOENCAS TRANSMISSIVEIS
/
GENETICA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
França
País de publicação:
Holanda