Your browser doesn't support javascript.
loading
Is anti-TNF switching in refractory Still's disease safe and effective?
Aikawa, Nadia Emi; Ribeiro, Ana Cristina de Medeiros; Saad, Carla Gonçalves Schain; Pereira, Rosa Maria Rodrigues; Levy, Mauricio; Silva, Clovis A; Bonfá, Eloísa; de Carvalho, Jozélio Freire.
Afiliação
  • Aikawa NE; Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Clin Rheumatol ; 30(8): 1129-34, 2011 Aug.
Article em En | MEDLINE | ID: mdl-21465126
Still's disease (SD) is a rare chronic inflammatory disease characterized by polyarthritis, systemic symptoms, and elevated inflammatory markers. Of note, 74 SD cases were reported with anti-tumoral necrosis factor (TNF) therapy and the experience of switching is limited to five patients. During a 3-year period, SD cases were 1.9% of 319 rheumatic patients that received anti-TNF agents in the infusion center of our University Hospital. In this manuscript, the authors add six new cases of refractory SD who had clinical and laboratory response to TNF blockers and report the outcome of switching in five of them. Partial or complete response was achieved by four of six (66.7%) patients and three of four (75%) required switching. Regarding safety, five of six (83.3%) had adverse events. Anti-TNF treatment with switching seems to be a valid approach for refractory SD patients.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Doença de Still de Início Tardio / Antirreumáticos / Substituição de Medicamentos / Anticorpos Monoclonais Limite: Adult / Female / Humans / Male Idioma: En Revista: Clin Rheumatol Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Doença de Still de Início Tardio / Antirreumáticos / Substituição de Medicamentos / Anticorpos Monoclonais Limite: Adult / Female / Humans / Male Idioma: En Revista: Clin Rheumatol Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha