Synergistic relaxing effect of the paracetamol and pyrilamine combination in isolated human myometrium.
Eur J Obstet Gynecol Reprod Biol
; 157(1): 22-6, 2011 Jul.
Article
em En
| MEDLINE
| ID: mdl-21439705
OBJECTIVE: To evaluate the interaction type of the human uterine relaxant effect of the paracetamol-pyrilamine combination (PPC) in vitro. STUDY DESIGN: Uterine strips were contracted with KCl (60 mM) and treated with vehicle or increasing concentrations of paracetamol (100-3200 µM), pyrilamine (3.2-100 µM) or the PPC. The relaxing effects of the drugs alone and in combination were measured. Isobolographic analysis was used to determine the pharmacologic interaction type. RESULTS: Paracetamol, pyrilamine and the PPC produced a significant relaxing effect on non-pregnant human uterine strips pre-contracted with KCl (60 mM). The EC30 values for paracetamol and pyrilamine on the uterine contraction were 2391.3±595.3 µM and 14.7±1.7 µM, respectively. The derived experimental EC30 for the PPC was 401.8±129.8 µM. This value was significantly lower (p<0.05) than the theoretical EC30 expected for a purely additive interaction, which was 1203.0±297.7 µM for the PPC. The interaction index (γ) was 0.33±0.14 for PPC, being statistically different from unity. CONCLUSION: Data suggest that low doses of the PPC can interact synergistically and therefore this drug association may represent a therapeutic advantage for the clinical treatment of dysmenorreic pain.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirilamina
/
Analgésicos não Narcóticos
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Antagonistas dos Receptores Histamínicos H1
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Acetaminofen
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Relaxamento Muscular
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Miométrio
Limite:
Adult
/
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Eur J Obstet Gynecol Reprod Biol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Irlanda