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Sudden unexpected death in an adolescent with epilepsy: all roads lead to the heart?
Pinto, Kylvia G F D; Scorza, Fulvio A; Arida, Ricardo M; Cavalheiro, Esper A; Martins, Luciana D; Machado, Helio R; Sakamoto, Américo C; Terra, Vera C.
Afiliação
  • Pinto KG; Centro de Cirurgia de Epilepsia (CIREP), Departamento de Neurociencias e Ciencias do Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Cardiol J ; 18(2): 194-6, 2011.
Article em En | MEDLINE | ID: mdl-21432828
The incidence of sudden unexpected death in epilepsy (SUDEP) has been estimated from 0.5-1.4/1,000 person-years in people with treated epilepsy, and 9/1,000 person-years in candidates for epilepsy surgery. Potential risk factors for SUDEP include: age, early onset of epilepsy, duration of epilepsy, uncontrolled seizures, seizure type and winter temperatures. The arrythmogenic side-effect of antiepileptic drugs and seizures may increase the risk of SUDEP. In this report, we describe a patient with prolonged post-ictal tachycardia in EEG video recordings with a typical case of SUDEP: a 16-year-old boy with medically intractable complex partial seizures. Magnetic resonance imaging revealed left mesial temporal sclerosis. During non-invasive video-EEG monitoring, the patient presented a post-ictal heart rate increased for five hours. Two months after video-EEG, he died from SUDEP during a tonic-clonic secondary generalized seizure. The possibility of cardiac involvement in the pathogenesis of SUDEP has been suggested by many studies. Evaluation of this patient with EEG-video monitoring, including measurement of heart rate, contributed to an identification of ictal tachycardia that may have played a role in the SUDEP. Premature mortality seems to be increased in patients with epilepsy, and cardiac abnormalities may be a possible cause of SUDEP.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Taquicardia / Morte Súbita Cardíaca / Epilepsia Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies Limite: Adolescent / Humans / Male Idioma: En Revista: Cardiol J Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Polônia
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Taquicardia / Morte Súbita Cardíaca / Epilepsia Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies Limite: Adolescent / Humans / Male Idioma: En Revista: Cardiol J Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Polônia