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Fibronectin- and laminin-mediated endocytic activity in the parasitic protozoa Trichomonas vaginalis and Tritrichomonas foetus.
Benchimol, M; Batista, C; De Souza, W.
Afiliação
  • Benchimol M; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brasil.
J Submicrosc Cytol Pathol ; 22(1): 39-45, 1990 Jan.
Article em En | MEDLINE | ID: mdl-2138055
The pathogenic protozoan Tritrichomonas foetus is able to ingest polystyrene particles with a diameter up to 1.0 micron. Trichomonas vaginalis, however, ingest particles as large as 4.4 microns in diameter. The particles are found within cytoplasmic membrane-bounded vacuoles. Morphometrical analysis showed that T. vaginalis presents a higher endocytic activity than T. foetus. Coating of the polystyrene particles with cationized ferritin increases their binding to the parasite surface but does not interfere with their ingestion. In contrast, coating with laminin significantly increased the uptake of the particles by both parasites while coating with fibronectin potentiates the ingestion of the particles only by T. foetus. These observations suggest the presence of laminin- and fibronectin-binding sites on the surface of trichomonads, an observation which is in agreement with the recent description of a receptor for laminin on the surface of trichomonads.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trichomonas vaginalis / Tritrichomonas / Endocitose Limite: Animals Idioma: En Revista: J Submicrosc Cytol Pathol Assunto da revista: PATOLOGIA Ano de publicação: 1990 Tipo de documento: Article País de afiliação: Brasil País de publicação: Itália
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trichomonas vaginalis / Tritrichomonas / Endocitose Limite: Animals Idioma: En Revista: J Submicrosc Cytol Pathol Assunto da revista: PATOLOGIA Ano de publicação: 1990 Tipo de documento: Article País de afiliação: Brasil País de publicação: Itália