Evidence for the participation of mast cells in the innate resistance of mice to Schistosoma mansoni: effects on in vivo treatment with the ionophore 48-80.
Braz J Med Biol Res
; 23(6-7): 559-65, 1990.
Article
em En
| MEDLINE
| ID: mdl-2129266
1. Evidence is presented for the participation of mast cells in the resistance of mice to infection by Schistosoma mansoni. 2. Intravenous injection of 1 micrograms/g body weight of the ionophore 48-80, a potent mast cell degranulator, significantly reduced (42-62%) the histamine content of the ear tissue of normal mice and either increased or decreased resistance to parasite penetration and infection depending on whether the injection of the ionophore was 5 min or 2 days before cercarial penetration. 3. When 48-80 was injected 5 min before the beginning of cercarial penetration, the number of parasites recovered from ear tissue 2 days later or from the portal system 30 days later was significantly reduced (39-71% and 27-40%, respectively) in relation to untreated controls. This resistance caused by 48-80 was blocked when mice were simultaneously treated with cyproheptadine, an antagonist of vasoactive amines. 4. In contrast, when 48-80 was administered 2 days before the beginning of cercarial penetration, the number of parasites retrieved from ear tissue 2 days later or from the portal system 30 days later was 32-64% and 28-30% larger, respectively, in relation to untreated controls. 5. These findings indicate that the local inflammatory reaction mediated by mast cells is important in the resistance of mice to infection with S. mansoni.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquistossomose mansoni
/
P-Metoxi-N-metilfenetilamina
/
Mastócitos
Limite:
Animals
Idioma:
En
Revista:
Braz J Med Biol Res
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil