[Prenatal dexametasone and periventricular leucomalacia in prematures]. / Uso prenatal de dexametasona para leucomalacia periventricular en niños prematuros.
Rev Med Inst Mex Seguro Soc
; 48(6): 635-8, 2010.
Article
em Es
| MEDLINE
| ID: mdl-21184719
BACKGROUND: Prematurity is observed in 5-8% of deliveries, and is frequent cause of handicap. Premature have 5-24% risk for developing periventricular leukomalacia (PLM). The use of antenatal steroids (AS) is controversial for preventing PLM. METHODS: We studied 110 premature neonates < 1500 g, divided in 2 groups: control (group 1, n = 55), and group 2 (n = 55) who received antenatal dexamethasone. We registered clinical data, evolution and use of oxygen or mechanical ventilation. At one month age a transfontanelar ultrasound was done looking specific PLM. RESULTS: In group 1, found 6/55 (10.9%) with PLM and 3/55 (5.4%) in group 2, RR = 0.5, CI 95% (0.13-1.90). In group 1: 30/55 (54.54%) the ultrasound was normal; in 16 (29%) had intraventricular haemorrhage, and in 3 cases (5.45%) had severe hydrocephalus. In group 2: 32/55 (58.18%) ultrasound was normal, 16/55 (29%) had intraventricular haemorrhage, 4/55 (7.27%) had severe hydrocephalus. We did not find significant difference between other variables in both groups. CONCLUSIONS: There was no significant difference in PLM incidence between patients who did or did not received antenatal dexamethasone.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucomalácia Periventricular
/
Dexametasona
/
Terapias Fetais
/
Glucocorticoides
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
/
Newborn
Idioma:
Es
Revista:
Rev Med Inst Mex Seguro Soc
Assunto da revista:
MEDICINA
/
MEDICINA SOCIAL
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
México