Intravenous infusions of nitroprusside, dobutamine, and nitroglycerin are compatible.
Crit Care Med
; 18(8): 858-61, 1990 Aug.
Article
em En
| MEDLINE
| ID: mdl-2116261
It is now customary practice to couple separately metered infusions via a manifold to a common catheter that enters the patient. Nitroprusside, however, is considered incompatible with all other medications. Critically ill patients who require multiple infusions of vasoactive and inotropic medications would benefit if physicians had additional information regarding compatibility of nitroprusside with other commonly used infusions. Utilizing high-performance liquid chromatography, the authors investigated the physical and chemical compatibility of nitroprusside, dobutamine, and nitroglycerin in solutions of 5% dextrose or 0.9% NaCl at clinically relevant concentrations. All drugs were present within the guidelines of the U.S. Pharmacopeia (+/- 10%) over 24 h in NaCl, but nitroglycerin degraded over 24 h when the three drugs were mixed in dextrose. We recommend diluting these medicines in NaCl when mixtures of them would exist for greater than 4 h.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nitroprussiato
/
Nitroglicerina
/
Dobutamina
/
Ferricianetos
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
En
Revista:
Crit Care Med
Ano de publicação:
1990
Tipo de documento:
Article
País de publicação:
Estados Unidos