Heart regeneration: Past, present and future.

Carvalho, Adriana Bastos; de Carvalho, Antonio Carlos Campos

Carvalho, Adriana Bastos; de Carvalho, Antonio Carlos Campos.

Afiliação

Carvalho AB; Adriana Bastos Carvalho, Antonio Carlos Campos de Carvalho, National Institute of Cardiology, Rio de Janeiro, RJ, CEP 22240-006, Brazil; Carlos Chagas Filho Institute of Biophysics and Institute for Science and Technology in Structural Biology and Bioimaging, Rio de Janeiro, RJ, CEP 21941-902, Brazil.

World J Cardiol ; 2(5): 107-11, 2010 May 26.

Article em En | MEDLINE | ID: mdl-21160711

RESUMO

The heart has been considered a post-mitotic organ without regenerative capacity for most of the last century. We review the evidence that led to this hypothesis in the early 1900s and how it was progressively modified, culminating with the report that we renew 50% of our cardiomyocytes during our lifetime. The future of cardiac regenerative therapies is discussed, presenting the difficulties to overcome before repair of the diseased heart can come into clinical practice.

Palavras-chave

Cardiac stem cells; Cardiomyocyte proliferation; Self-renewal; Stem cell-based therapies

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: World J Cardiol Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

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