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Acute ingestion of alcohol and cardiac autonomic modulation in healthy volunteers.
Bau, Paulo F D; Moraes, Ruy S; Bau, Claiton H D; Ferlin, Elton L; Rosito, Guido A; Fuchs, Flávio D.
Afiliação
  • Bau PF; Department of Clinical Medicine, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil. paulobau@gmail.com
Alcohol ; 45(2): 123-9, 2011 Mar.
Article em En | MEDLINE | ID: mdl-21131160
Arrhythmogenic effects of alcohol may be intermediated by its effects over heart rate variability (HRV). Most studies about the effects of alcohol over HRV were observational and did not explore the temporal influence of alcohol ingestion over autonomic modulation. The aim of this study was to verify if an acute ingestion of alcohol has a time-dependent influence over time-domain indices of HRV. The effect of the ingestion of 60 g of ethanol or placebo over autonomic modulation was compared in healthy men (35 per group), with 18-25 years of age, before and during 17 h after ingestion. Alcohol promoted a fall in the standard deviation of all normal R-R intervals, root mean square of successive differences, and percentage of pairs of adjacent R-R intervals differing by more than 50 ms and in two indices of the three-dimensional return map, by a period up to 10 h after the ingestion of alcohol, accompanied by an increase in heart rate. The indices returned to values similar of the control group 10 h after ingestion. The effects over HRV indices were attenuated by adjustment for heart rate. The ingestion of alcohol induces a broad cardiovascular adaptation secondary to vagal withdrawal and sympathetic activation that may be responsible for arrhythmogenic effects of alcohol ingestion.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Autônomo / Etanol / Frequência Cardíaca Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Adult / Humans / Male Idioma: En Revista: Alcohol Assunto da revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Autônomo / Etanol / Frequência Cardíaca Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Adult / Humans / Male Idioma: En Revista: Alcohol Assunto da revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos